Bone Graft Alternatives
There are a variety of bone graft substitutes that are available for use in spine fusion surgery or are being evaluated in various stages of clinical trials. In general, these types of bone graft are a synthetic or manipulated type of a naturally-occurring product.
There is a lot of interest in developing and refining bone graft substitute options for use in lumbar spinal fusion surgery procedures in order to eliminate the need to harvest the patient’s own bone, thus potentially reducing the risk and pain associated with the procedure and resulting in higher fusion rates.
There are several main types of bone graft substitutes used in spinal fusion surgery, which can be generally categorized into three main areas:
- Demineralized Bone Matrix (DBM)
Processing of allograft bone (cadaver bone graft) can be manipulated (demineralized) to extract the proteins that stimulate bone formation. These proteins are processed and available in various forms, such as chips, gel, putty or powder. This type of product is called a demineralized bone matrix, and it can be readily used in place of or as an extender to the patient’s own bone.
Although it has successfully fused spines in animal studies, there is no proof that this is a powerful enough stimulus to successfully fuse a human spine; therefore, it is not recommended for use without the addition of the patient’s own bone. It is only recommended as a bone graft extender and not as a replacement.
DBM is usually considered a bone graft extender rather than a replacement because its ability to fuse the human spine alone is not proven. As such, DBM can be mixed with a regular bone to obtain more graft volume when it is needed for fusion.
- Synthetic Bone Graft Extenders
There are several substances such as ceramics, calcium phosphates and other synthetic materials that have similar biomechanical properties and structure similar to that of cadaver bone and may be used as a bone graft substitute. They allow for bone growth on their surface and then they are resorbed by the body, with the patient’s own bone remaining in place.
However, these products do not have all the properties necessary to stimulate spinal fusion when used alone. They are usually used in combination with the patient’s own bone to augment the amount of bone graft available.
When the patient’s bone marrow cells (bone marrow aspirate) are added to ceramics, clinical studies have demonstrated that these products are effective.
Unlike allograft (cadaver bone), ceramic-based products do not present a risk for disease transfer. However, they may occasionally cause inflammation.
- Bone Morphogenetic Proteins (BMP)
Bone morphogenetic proteins (BMP) stimulate bone growth naturally in the human body. These proteins that exist in the body can be produced, concentrated and placed in the area of the spine for a spinal fusion to take place. More importantly, they can create fusion without the need for any use of the patient’s own bone. Types of Bone Morphogenetic Proteins (BMP)
While there are several different BMPs naturally found in the body, research has focused on BMP-2 and BMP-7. BMP-2, the most thoroughly evaluated BMP, in particular, has been shown through clinical studies to successfully stimulate spinal fusion equal to or better than the patient’s own bone.
We Are Spine is a specialized clinic that provides treatment for various types of spine diseases, whether acute or chronic.Our team of well-known Spine Specialists in Mumbai with years of expertise in clinical practice has helped over 60000 patients overcome back pain. The clinic boasts of a highly experienced team of spine specialists and Best Spine Surgeon Mumbai who are supervised by Dr. Shekhar Bhojraj, one of the top spine surgeons in Mumbai.
We Are Spine utilizes the latest technologies and equipment to minimize spine surgery and achieve better results. With their expertise and dedication, the clinic is committed to providing the best possible care for patients suffering from spine-related ailments.
WEARESPINE is an advanced and dedicated spine clinic in Mumbai for patients with spine issues in Mumbai, India. The spine is a crucial part of the body, supporting the head and upper body weight, protecting the spinal cord, and allowing movement. Spinal problems can lead to pain, discomfort, and disability. Choosing the best spine surgeon in Mumbai is essential for effective spine care and treatment. We Are Spine boasts a team of top spine surgeons in mumbai, including experts like Dr. Shekhar Bhojraj, Dr. Abhay Nene, Dr. Priyank Patel, Dr. Sheetal Mohite, Dr. Premik Nagad, and Dr. Raghuprasad Varma, specializing in minimally invasive and robotic-assisted spine surgery in Mumbai . With over 60,000 patients treated, we offer offer comprehensive care, advanced technology, and affordability. Services include minimally invasive spine surgery, complex spine surgery, spinal fusion, and artificial disc replacement. Common conditions treated include herniated discs, spinal stenosis, degenerative disc disease, scoliosis, and spinal fractures. Choose We Are Spine for expert, patient-centered care in Mumbai.
At The We are spine we offer the most advanced and
effective bespoke treatment packages to suit your needs
For effective pain treatment, it is imperative to diagnose the underlying condition.
Depending on the diagnosis, our first choice for treatment are rehabilitation…
We advise surgical intervention only when the risk of surgery is far lower than the risk of leaving…
We guide individuals on how to prevent first or recurrent back pain by suggesting lifestyle…