Bone Graft Alternatives

Bone Graft Alternatives

There are a variety of bone graft substitutes that are available for use in spine fusion surgery or are being evaluated in various stages of clinical trials. In general, these types of bone graft are a synthetic or manipulated type of a naturally-occurring product.

There is a lot of interest in developing and refining bone graft substitute options for use in lumbar spinal fusion surgery procedures in order to eliminate the need to harvest the patient’s own bone, thus potentially reducing the risk and pain associated with the procedure and resulting in higher fusion rates.

There are several main types of bone graft substitutes used in spinal fusion surgery, which can be generally categorized into three main areas:

  • Demineralized Bone Matrix (DBM)

    Processing of allograft bone (cadaver bone graft) can be manipulated (demineralized) to extract the proteins that stimulate bone formation. These proteins are processed and available in various forms, such as chips, gel, putty or powder. This type of product is called a demineralized bone matrix, and it can be readily used in place of or as an extender to the patient’s own bone.

    Although it has successfully fused spines in animal studies, there is no proof that this is a powerful enough stimulus to successfully fuse a human spine; therefore, it is not recommended for use without the addition of the patient’s own bone. It is only recommended as a bone graft extender and not as a replacement.

    DBM is usually considered a bone graft extender rather than a replacement because its ability to fuse the human spine alone is not proven. As such, DBM can be mixed with a regular bone to obtain more graft volume when it is needed for fusion.
  • Synthetic Bone Graft Extenders

    There are several substances such as ceramics, calcium phosphates and other synthetic materials that have similar biomechanical properties and structure similar to that of cadaver bone and may be used as a bone graft substitute. They allow for bone growth on their surface and then they are resorbed by the body, with the patient’s own bone remaining in place.

    However, these products do not have all the properties necessary to stimulate spinal fusion when used alone. They are usually used in combination with the patient’s own bone to augment the amount of bone graft available.

    When the patient’s bone marrow cells (bone marrow aspirate) are added to ceramics, clinical studies have demonstrated that these products are effective.

    Unlike allograft (cadaver bone), ceramic-based products do not present a risk for disease transfer. However, they may occasionally cause inflammation.

  • Bone Morphogenetic Proteins (BMP)

    Bone morphogenetic proteins (BMP) stimulate bone growth naturally in the human body. These proteins that exist in the body can be produced, concentrated and placed in the area of the spine for a spinal fusion to take place. More importantly, they can create fusion without the need for any use of the patient’s own bone. Types of Bone Morphogenetic Proteins (BMP)

    While there are several different BMPs naturally found in the body, research has focused on BMP-2 and BMP-7. BMP-2, the most thoroughly evaluated BMP, in particular, has been shown through clinical studies to successfully stimulate spinal fusion equal to or better than the patient’s own bone.

  • We Are Spine is a specialized clinic that provides treatment for various types of spine diseases, whether acute or chronic.Our team of well-known Spine Specialists in Mumbai with years of expertise in clinical practice has helped over 60000 patients overcome back pain. The clinic boasts of a highly experienced team of spine specialists and Best Spine Surgeon Mumbai who are supervised by Dr. Shekhar Bhojraj, one of the top spine surgeons in Mumbai.

    Introducing the team of our spine surgeons – Dr. Abhay Nene, Dr. Shital Mohite, Dr. Priyank Patel, Dr. Premik Nagad , Dr. Aaditya D. Kashikar and Dr. Harshal Babulal Bamb !

    We Are Spine utilizes the latest technologies and equipment to minimize spine surgery and achieve better results. With their expertise and dedication, the clinic is committed to providing the best possible care for patients suffering from spine-related ailments.

WEARESPINE is an advanced and dedicated spine clinic in Mumbai  for patients with spine issues in Mumbai, India. The spine is a crucial part of the body, supporting the head and upper body weight, protecting the spinal cord, and allowing movement. Spinal problems can lead to pain, discomfort, and disability. Choosing the best spine surgeon in Mumbai is essential for effective spine care and treatment. We Are Spine boasts a team of top spine surgeons in mumbai, including experts like Dr. Shekhar Bhojraj, Dr. Abhay Nene, Dr. Priyank Patel, Dr. Sheetal Mohite, Dr. Premik Nagad, and Dr. Raghuprasad Varma, specializing in minimally invasive and robotic-assisted spine surgery in Mumbai . With over 60,000 patients treated, we offer offer comprehensive care, advanced technology, and affordability. Services include minimally invasive spine surgery, complex spine surgery, spinal fusion, and artificial disc replacement. Common conditions treated include herniated discs, spinal stenosis, degenerative disc disease, scoliosis, and spinal fractures. Choose We Are Spine for expert, patient-centered care in Mumbai.

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Patients’ Testimonials

Satyam Bairoliya
Satyam Bairoliya
2023-07-17
On behalf of my grandfather- I met up with Dr Abhay due to a disk prolapse (Slip Disk). Dr abhay started off by giving me a comfortable space to share my problems especially given the fact that hailing from a small town it was not everyday that a doctor asked a lot of relevant questions ensure the best remedy. Dr abhay suggested me to undergo a regular physiotherapist sessions, that’s when I was introduced to Dr.Shikha. Her sessions were extremely simple to understand. Given the fact that it was done over video it was all the more impressive. I have been gradually recovering my strength and Dr.Abhay’s regular followups ensured the correct steps are being followed throughout the journey to ensure that i avoid surgery. Truly in line with the catchphrase “we are spine” Thanks for everything 😄
Geeta Jaisinghani
Geeta Jaisinghani
2023-07-16
hi I am geeta Jaisinghani, senior citizen, from mumbai. I was going thru severe back n neck pain. No doctors n physios really cud help me. Finally my son contacted Dr Abhay Nene ( whom we know sync several years )on video calling n he saw my reports n said only physio wil give complete relief n no need for any surgery. He advised some walking posture n told me to contact Dr. Shikha Jain. Dr Nene said she wil give best help to me n truly I cud not believe in just the first few sessions itself I got soo much relief. she was very confident n had patience in training me thru zoom meeting. I thank God for Dr. Nene and Dr. Shikha Jain. They r the bestest I hav known n cud refer to anyone. God bless them both as they r truly dedicated to their work and caring.
Saju Thomas
Saju Thomas
2023-07-16
I am from Kerala. I suffered a lot because of my chronic backache. The pain radiated to my arms as well as the legs , and caused numbness and weakness. I was in a situation where I can't do my everyday routine.Other doctors suggested me for surgery or else there will be a condition to sit on a wheelchair. At this point one of my friend Rohit Gokhle suggested about we are spine team, and decided to give it a try. Now I think this was the best decision I ever made. The team of we are spine helped me for a fast recovery. Especially Dr. Shika Jain. Dr. did a great job with my first ever health exam. She explained everything to me in a very clear manner. Not only has she taken great care of my health, but also she is lovely to speak with at every appointment. It's rare to find a doctor that combines such personal touches and care for a patient as a person with outstanding quality of medical care. I am so glad I chose we are spine team and would highly recommend to anyone.
urvi ghatalia
urvi ghatalia
2023-07-16
A Life-changing Journey with WeAreSpine I had been struggling with excruciating spasms in my legs and lower abdomen and the pain was making it difficult to carry out my daily activities. I consulted my doctor Dr Abhay Nene of WeAreSpine who asked me to see Dr Priyank Patel, as he was travelling. And, it turned out to be a life-changing experience. Upon consulting Dr. PRIYANK Patel, I was advised to try physiotherapy as a solution to my problem. This led me to the capable hands of Dr. Shikha, who guided me through a series of specific exercises aimed at strengthening the muscles supporting my lower back. The results were astounding. Within just a month of consistent effort and dedication, I noticed a remarkable 90% improvement in my condition. The excruciating pain and spasms that once plagued my daily life were now significantly reduced, allowing me to regain my mobility and enjoy life to the fullest. I cannot emphasize enough how grateful I am to the team at WeAreSpine for their expertise and exceptional care. Dr. Abhay Nene’s diagnosis and Dr. Shikha's tailored physiotherapy exercises were the key to my recovery. If you are facing any spine-related issues or pain, I wholeheartedly recommend WeAreSpine. Their compassionate and skilled approach to spinal health is unmatched. My journey with them has been nothing short of incredible, and I now feel equipped to face life with renewed vigor and a pain-free existence. Thank you, WeAreSpine!
Devendra Parulekar
Devendra Parulekar
2023-07-16
A freak incident caused a pinched nerve that sent radiating pain down my arm, with reduced power caused by a possible damage to the nerve. Being Founder of a Travel & Hospitality startup (SaffronStays), this meant a break from active work and travel, as this needed bed rest for a many weeks on end. What was troubling was that I had a long overdue family trip to France and Italy, in under 2 weeks! What complicated things was the emergency root canal that suddenly emerge exactly 2 days after the freak pinched nerve incident. In all this, renowned and celebrated Dr Abhay Nene and his trusted Physiotherapist Dr Shikha Jain, took over the challenge of putting me on that plane to Paris, without any surgery or steroid epidurals, with minimal pain! We actively and slowly increased the intensity of our neck and trapezius muscle exercises. Dr Shikha understood the root cause - a poor posture, caused excessive laptop/ mobile use - diagnosed as Forward Head Posture (also called Google neck) and literally forced me to first solve this by undertaking active posture correction exercises, including the famous McKenzie method or chin tucks and thoracic extensions. I recall her saying “Mr Deven, if you don’t do this exercise every day, you will have permanent nerve damage”. That shook me out of my inertia! Slowly and steadily, under Dr Abhay’s watchful eye, Dr Shikha increased the intensity of our exercise, by adding weights; to strengthen shoulder, back, neck and spine (also core) and now the affected triceps and biceps muscles, to get me back on the tennis court that I cannot live without. Am still a month or two away from my favourite sport, and eagerly waiting for the process of pain management, to pain Centralization, to paid reduction, muscle strengthening… much beyond the posture correction. What a brilliant journey, that straddled corrective to preventive methods. Kudos to this brilliant team of spine specialists!
Karan Bhatt
Karan Bhatt
2023-07-15
Hi , myself Dr karan was suffering from cervical cord compression at C5-C6 level for which I consulted Dr.ABHAY NENE sir who examined me and reassured me that it can be managed conservatively for which he suggested me to have a consult with Dr. Shikha jain . I would admit without a doubt that Dr.ABHAY sir’s guidance and physiotherapy by Dr. Shikha helped me regain my confidence and have been asymptomatic bcoz of the physiotherapy .Dr. Shikha has been upto the point ,very concerned and supportive throughout the treatment. I would highly recommend WE ARE SPINE for anyone suffering from spine ailments .
Jayshree Bhanushali
Jayshree Bhanushali
2023-07-15
Basically I am from Andhra pradesh and i have a spine issue for over the years. Just to consult Dr. Priyank ,i visited his clinic and really he is a great doctor. He is very understanding & listen to our concerns. He takes time with the patient to help them with their health issues.when you have an appointment, Dr. priyank will spend the whole scheduled period with the patient if need be. I am still addressing Dr. priyank but he had made me feel that i am in good hands.Really effecinet, on point, respectful and his staff is great. And Dr. keshav is also an awesome doctor. He suggested me to go for physiotherapy and i must say that Dr. shikha Jain is one of the best physiotherapist I have ever seen in my life.She is so sweet and for me she is like my daughter. She is very thoroughlthorough & caring. If you need a great doctor to help you with your health and wellness do yourself a favor and meet this adorable doctor Shikha. I can't imagine going anyone else now.
Gaurav Antapurkar
Gaurav Antapurkar
2023-07-14
I’ve been suffering with lower back pain(bulging disk and sciatica) from past 4 years. Till date I’ve consulted around 10 specialists with little to no relief. But ever since I am under the supervision of We are Spine I can say I feel a whole lot better than I was before. The pain is none to minimal. The treatment is completely medicine-free and addresses the root cause. I will highly recommend this to anyone with any kind of pain. Thank you We are Spine!
Gauraw Mishra
Gauraw Mishra
2023-03-21
I had a severe case of coccydynia, which was affecting my daily life. Dr. Shekhar Bhojraj provided me with an effective treatment plan, which included a combination of physical therapy and medication. The staff at We Are Spine Clinic was also very helpful, and I am now feeling much better.

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